Antibody Wars: Extreme Diversity

Antibody wars: extreme diversity.

Ethnic diversity, economic performance and civil wars

We develop a con‡ict model linking dissipation to the distribution of the population over an arbitrary number of groups. We extend the pure contest version of the model by Esteban and Ray (1999) to include a mixed public-private good. We analyze how the level of dissipation changes as the population distribution and the share of publicness of the prize change. First, we …nd that, in case of pur...

Reshaping Antibody Diversity

Some species mount a robust antibody response despite having limited genome-encoded combinatorial diversity potential. Cows are unusual in having exceptionally long CDR H3 loops and few V regions, but the mechanism for creating diversity is not understood. Deep sequencing reveals that ultralong CDR H3s contain a remarkable complexity of cysteines, suggesting that disulfide-bonded minidomains ma...

Extreme conformational diversity in human telomeric DNA.

DNA with tandem repeats of guanines folds into G-quadruplexes made of a stack of G-quartets. In vitro, G-quadruplex formation inhibits telomere extension, and POT1 binding to the single-stranded telomeric DNA enhances telomerase activity by disrupting the G-quadruplex structure, highlighting the potential importance of the G-quadruplex structure in regulating telomere length in vivo. We have us...

Clone Wars

Code clones, the result of the ”copy&paste” programming technique, have negative impact on software quality and on the efficiency of the software maintenance process. Although copying may be the fastest way of creating a new feature, after a while it is really hard to detect and maintain the multiple instances of the same code snippets. Based on static source code analysis, clone detectors try ...